Combining functional and tubular damage biomarkers improves diagnostic precision of acute kidney injury after cardiac surgery.
Rajit K. Basu, et al. JACC 2014;64:2753-62.
Objective: Combining two biomarkers will improve precision of acute kidney injury (AKI) diagnosis after heart surgery in children.
Methods: n=345 children after cardiopulmonary bypass (CPB). Two biomarkers: Plasma Cystatin C & uNGAL were measured 2 hr after initiation of CPB.
Conclusion: Composites of plasma Cystatin C and uNGAL are superior to serum creatinine for predicting discrete characteristics of AKI.
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