NEJM 2008;358:2787-95
(Click on image to enlarge)
18 pediatric patients were treated (17 received Lorsartan, 1 received Ibesartan).
Age range:1 -16 yrs (median age 6.5 yrs)
Duration of study: Median 6 yrs (~4 yrs before starting ARB & ~ 2 yrs after starting ARB)
Dose:
Losartan - started at 0.6 mg/kg/day x 3 wks. Then, gradually increased to 1.4 mg/kg/day.
Ibesartan - started at 1.4 mg/kg/day. Then, gradually increased to 2.0 mg/kg/day.
Check BUN, Creatinine, Electrolytes after 3 months.
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