Saturday, June 19, 2010

Radiation Safety: Dose reduction using Phillips DoseWise(R) System

Management of pediatric radiation dose using Phillips fluoroscopy systems DoseWise: perfect image, perfect sense. Stueve,D. Pediatr Radiol 2006;36(Suppl 2):216-220.

Phillips DoseWise: a set of techniques, programs and practices that ensure optimal image quality with minimum radiation.

Eleva system for fluoroscopy & Allura system for angiography incorporate DoseWise.

Smart beam management: Based on the selection of exam-type and patient-type, EPX-based program automatically selects the following:
- Radiographic exposure factors
- Focal spot size
- Spectral filtration
- Fluoroscopy type, dose and exposure rate

Radiographic Exposure Factors:
Grid-controlled Fluoroscopy (GCF) vs. Continous fluoroscopy, saves radiation. These are designed to maintain 70kV level even in very small patients.

IQX (Intelligent Exposure Control) rapidly regulates digital radiographic exposures when children are imaged.

Spectral beam filter:
"Soft radiation" (X-rays that enter patient's skin but do not have enough energy to reach image detector) are removed from the beam. Such filtration reduces dose to patient and personnel. Depending on patient size & type of exam, the filters are automatically inserted into the beam:

Copper spectral filters (0.1mm, 0.2 mm, 0.4 mm and 0.9 mm thickness)
&
Aluminum spectral filter (1 mm thickness)

Typically, 0.1 mm Cu filter reduces exposure by 50% & 0.2 mm by 70%.
Typically, 0.1 & 0.4 mm Cu filters are used in adult interventional procedures where long exposure times are common.
0.9 mm Cu filter is used for newborn & small children; and also for long EP procedures.
In cardiac & vascular procedures, 0.1 mm Cu filter & 0.4 mm Cu filter provide max. exposure of 10 R/min and 5 R/min respectively during fluoroscopy. (0.9 mm Cu filter provides 1.5 R/min max).
In standard pediatric radiology, 0.1 mm Cu filter provides best relationship best diagnostic images with lowest dose.

Customizing beam shape: 3 successive steps
1) Lead iris shape shutter (at the outlet port of X-ray tube)
2) Two Lead square shutters (positioned above 1)
3) Copper wedge filters within collimator
These shutters and wedges can be adjusted on Last-image-hold image (without using extra radiation to adjust these).

Adaptive Measuring Field (AMF):
When the field is panned through anatomic structures of varying (radio)opacity, brightness of fluoroscopic image changes. Automatic Exposure Control (AEC) - designed to maintain consistent image brightness level - would respond and increase X-ray dose to maintain brightness when very opaque object comes into the field. (Same occurs when collimator shutter are closed too small). AMF system continously monitors shutter position and uses sensors from the included areas only to set radiation output.

AEC lock-in helps to maintain image quality during panning through objects that are too dark and too light on the field. Thus, it eliminates "blooming".

Radiation-on time:
1) In-pulse radiation control (IQX) - Radiographic settings (tube voltage - kV, tube current - mA and pulse width - ms) are adjusted within the first millisecond of exposure.
2) Pulsing the beam during fluoroscopy (vs. Traditional, continous beam)
For fluoroscopy, GCF is used.
For angiography, IQX is used.

GCF (Grid-controlled Fluoroscopy):
GCF extends the in-pulse control concept to pediatric fluroscopy curves @ short pulse widths.
Production instant rise and fall of exposure (creating "square pulse"; achieved by DoseWise "Grid Switching") in stead of pulses with slight "ramp" in rise and fall (in "conventional pulse fluoroscopy") decreases radiation dose by 80-90%.
Grid switching also reduces soft radiation & motion blur.
(Two studies demonstrated GCF system reduced radiation dose between 4.6 - 17 times compared to conventional fluoroscopy: In children - Pediatr Radiol 2000;30:236-42 & In pigs - Radiol 2006;238:96-106).

Display of radiation exposure on physician's monitor display:
Air kerma dose levels
Dose Area Product (DAP) - measured from a meter located in X-ray tube collimator
Future: Display of patient entrance dose - monitored from predetermined points on patients body to warn when it approaches deterministic damage level.

Using (cerebral & renal) NIRS in Tilt Table Testing in Children


Thursday, June 10, 2010

Surgery: pH stat is superior to alpha-stat in infants

Perioperative effects of alpha-stat versus pH-stat strategies for deep hypothermic cardiopulmonary bypass in infants. Adre J. du Plessis et al. JTVCS 1997;114:991-1001.

Randomized, single-center trial in infants, n=182 (90 alpha-stat & 92 pH-stat)
Early death : 4 in alpha-stat, 0 in pH-stat
EEG seizures: 5/57 in alpha-stat, 1/59 in pH-stat
Clinical seizures: 4 in alpha-state, 2 in pH-stat
First EEG activity occurred sooner in alpha-stat gp.
Higher CI, lower inotrope requirement, less frequent acidosis & hypotension and shorter ventilation time.
Conclusion: pH stat is superior to alpha-stat in infants.

Method:
Alpha-stat - During induction of hypothermia, there is a natural tendency for blood to become more alkalotic. With no intervention, this constitutes alpha-stat strategy.
pH-stat: Patient's pH is read from blood gas analyzer at 37 deg C. pH is adjusted to 7.40 at patient's tympanic membrane temperature using a nomogram. This is accomplished by addition of CO2 to the ventilating gas in the oxygenator during cooling and low-flow bypass. During rewarming, alpha-stat management is instituted for all patients.

Blood flow during cooling and rewarming was 150 ml/kg/min; during low-flow bypass 50 ml/kg/min. Patients were rewarmed to a rectal temperature of 35 deg C.

Discussion:
pH-stat causes cerebral vasodilatation. Cerebral oxygen supply is enhanced with decreased use. Alternative explanation is extracellular acidosis noted in pH-stat strategy inhibits cerebral excitotoxicity. And, CO2 used in pH-stat strategy seems to have suppressive effect on cerebral metabolic rate - decreasing oxygen demand. In rodents, intraischemic CO2 is neuroprotective.

Wednesday, June 9, 2010

ICU: Hypertonic-hyperoncotic solution, Postop cardiac patients




Hypertonic-hyperoncotic solutions improve cardiac function in children after open-heart surgery
Schroth, M. et al. Pediatr 2006;118:e76-e84


Two groups of 25 children, after ASD/VSD closure. One group received HES (Poly hydroxy ethyl starch - Osmolarity: 2464 mOsmol/L). Second group received Isotonic normal saline (309 mOsmol/L).
Staff are blinded to the solution. All patients received either HES or NS 4 ml/kg over 15 min. Hemodynamic parameters were measured using Thermodilution and PiCCO (Pulse contour Cardiac Output) technique...PULSION Medical Systems.
Measurements were taken before, immediately after, 15 min, 1 hr, 4 hr, 12 hr and 24 hrs after volume loading.
HES group (called HHS group in paper): CI ws 3.6 L/min/m2(before) - Increased to 5.96 L/min/m2 immediately after.
Remained elevated at 15 min and 60 min. Lasted upto 4 hrs.
Normal saline group (called ISS group in paper): No change was noticed. 3.39 L/min/m2 before & 3.65 after.

Monday, June 7, 2010

Congenital Heart Block - Maternal Lupus

Dexamethasone therapy & Outcome
Friedman, D. et al. PRIDE study group.
Circulation 2008;117:485-93.


http://docs.google.com/fileview?id=0B5SNr50OQN-XZDczMWY5NmYtNTYwMi00NGZhLWExZTItYTkyNjM3Y2UxNThj&hl=en


Maternal antibody titre is an important predictor of congenital heart block.
Jaeggi, E. et al. JACC 2010;55:2778-84

http://docs.google.com/fileview?id=0B5SNr50OQN-XNTZmZmYxMDktMDY5OS00MzM1LWJkZGQtNzEzODg3MjgyNmVi&hl=en

Saturday, June 5, 2010

Cath: PDA coil closure in preterm

J Am Coll Cardiol Intv. 2010;3(5):550-5
Transcatheter occlusion of patent ductus arteriosus in pre-term infants. Edwin Francis, Anil Kumar Singhi, Srinivas Lakshmivenkateshaiah, Rama Krishna Kumar kumar_rk@yahoo.com Report 8 infants. Weight at the time of procedure: 900 - 1700 (median 1100) g. Gestation: 27-32 wks. PDA size: 2 - 3.5 mm
Coil size: All coils were 0.038; 1 to 3 coils were placed in each patient.
PDA size - Coil size - Number of coils
2.5 mm 5-5 2
2.5 mm 5-5 2
2 mm 5-5 2
3.5 mm 5-6 3
2.5 mm 3-4 1
3 mm 3-4 2
2.5 mm 3-4 2
2.2 mm 3-4 2
Access: 4 Fr via Femoral vein (Arterial access only when already present or obtained accidentally)
Procedure has multiple nuances described.
Placement of sheath: 24 G cannula -> 0.014 coronary guide wire -> Insert the cannula well into fem. vein -> 0.018 short wire -> 4 Fr Micropuncture sheath (Cook) -> Exchange to 4 Fr (5 Fr in 1 pt,) short introducer sheath
4 Fr JR catheter. Place at junction of IVC-RA; 0.025 Terumo wire to advance to RV - PDA - DAo. (Online video)
Over Terumo wire, advance 4 Fr long sheath (25 cm; Cook) and place tip in DAo.
PDA angiogram via this long sheath after pulling back into PDA - with wire still in place (Note: No arterial access in a typical case).
Coils delivered using Bioptome. Coils tied with 3-0 Prolene, held in bioptome, pulled inside a 4 Fr loader (short) sheath...transfer from loader to 4 Fr long sheath...advance and deliver.
Fluoroscopy time: 8.1 (+/- 1.9) min, Range: 4.8 - 11.3 min
Complications: None. No embolizations.