Monday, February 21, 2011

ProBNP in newborn with PDA

Article
Arch Dis Child Fetal Neonatal Ed 2008'93:F257-F260.

49 infants were analyzed (median GA 30 wks, weight 1220g)
18 had hemodynamically-significant PDA - Day 3 NT-proBNP was high (median 32,907 pg/ml; Range: 11,396 - 127,155 pg/ml).
31 controls (no PDA, no Sepsis) - Day 3 median NT-pro-BNP was 3147 pg/ml (Range: 521 - 10,343 pg/ml).

Cut-off value for Day 3, NT-pro-BNP is 11,395 pg/ml for hemodynamically-significant PDA (Sensitivity 100% and Specificity 95%)

Sepsis: Day 10 NT-pro-BNP was elevated in infants who developed sepsis. Animal studies suggest that inflammatory cytokines may stimulate production and release of BNP during sepsis.

1 comment:

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