Showing posts with label Risk Stratification. Show all posts
Showing posts with label Risk Stratification. Show all posts

Sunday, March 11, 2012

Risk Stratification in Brugada Syndrome

Results of PRELUDE (PRogrammed ELectrical stimUllation preDictive valuE) Registry.

SG Priori et al.

JACC 2012;59:37-45.

Study of 247 men (Median age 44 yrs, Range 18-72 yrs)

Results: During a median follow-up of 34 months, 14 arrhythmic events (4.5%) occurred (13 appropriate shocks of the implantable defibrillator, and 1 cardiac arrest). Programmed electrical stimulation performed with a uniform and pre-specified protocol induced ventricular tachyarrhythmias in 40% of patients: arrhythmia inducibility was not a predictor of events at follow-up (9 of 14 events occurred in noninducible patients). History of syncope and spontaneous type I ECG (hazard ratio [HR]: 4.20), ventricular refractory period <200 ms (HR: 3.91), and QRS fragmentation (HR: 4.94) were significant predictors of arrhythmias.

Conclusions: Our data show that VT/VF inducibility is unable to identify high-risk patients, whereas the presence of a spontaneous type I ECG, history of syncope, ventricular effective refractory period <200 ms, and QRS fragmentation seem useful to identify candidates for prophylactic implantable cardioverter defibrillator.

Thursday, April 21, 2011

Heart risk factors high in young Indian adults









By Amy Norton
NEW YORK Wed Apr 20, 2011 6:29pm EDT

NEW YORK (Reuters Health) - More and more, young urban adults in India are developing obesity, high blood pressure and diabetes -- suggesting that rising rates of heart disease could be in the future, a new study finds.
Among 1,100 young adults from New Delhi, all three conditions became steadily more common over the 7 years of the study. And all are known to contribute to heart disease.
At the outset, when the average study participant was 29 years old, about 50 percent had waistlines that fit the criteria for abdominal obesity. Seven years later, that was true for 70 percent.
Meanwhile, rates of high blood pressure rose from 11 percent to 34 percent among men, and from 5 percent to 15 percent among women. Diabetes also became a growing problem -- with the rate rising from 5 percent to 12 percent among men, and from 3.5 percent to 7 percent among women.
Those "remarkable changes" in such a short time suggest that these young adults could have high rates of heart disease and stroke down the road, the researchers warn.
The findings, reported in the Journal of the American College of Cardiology, add to a bleak outlook for Indians' heart health.
The country of 1 billion-plus was estimated to account for 60 percent of the world's heart disease cases in 2010. And a recent study found that people in India and other South Asian countries suffer their first heart attack at age 53, on average -- 6 years earlier than the rest of the world.
Dr. Dorairaj Prabhakaran, who worked on the new study, was not surprised at how common heart disease risk factors were even in this young population.
"Given the rapid socioeconomic and demographic transitions in India, I was not surprised at the high incidence rates," Prabhakaran, a cardiologist at the Center for Chronic Disease Control in New Delhi, told Reuters Health in an email.
Western-style diets often catch the blame for feeding obesity and its associated health problems, Prabhakaran noted. But such eating habits are not that common in India.
"Many popular Indian foods are unhealthy, as they are rich in sugar and saturated fat," said Prabhakaran.
He added that many traditional Indian foods are high in salt, while popular inexpensive foods like biscuits and other baked goods contain trans-fat -- which can not only raise "bad" LDL cholesterol but also lower heart-healthy HDL cholesterol.
Bigger portions of those foods, decreasing physical activity, and other heart threats like smoking could be behind the current findings.
And while the study looked only at young adults in New Delhi, Prabhakaran said that heart risk factors in rural areas of southern India have risen quickly in the last decade and are near the levels seen in urban areas.
"Reducing cardiovascular disease and its risk factors requires a policy response," Prabhakaran said, "particularly tobacco control, making fruits and vegetables available locally and affordable, and an enabling environment to improve physical activity."
Heart disease and its risk factors put a "huge" financial burden on the Indian people and healthcare system, Prabhakaran and his colleagues point out.
The annual cost of treating diabetes, for example, consumes anywhere from 5 percent to 34 percent of personal income in India.
An editorial published with the study agreed on the need for tobacco control and other public policies aimed at improving heart health in India.
Health education is not enough because "smoking, sedentariness, and poor diet do not arise in a vacuum," write Drs. Gilles Paradis, of McGill University in Montreal, Canada, and Arnaud Chiolero of the University of Lausanne in Switzerland.
"The task is daunting," they write, "but we have a moral obligation to support the global fight against (cardiovascular disease) and chronic diseases, which are the pandemic of the twenty-first century."
SOURCE: Journal of the American College of Cardiology, April 26, 2011.

Tuesday, April 19, 2011

Risk Categories in Cath Procedures







Circulation: Cardiovascular Interventions.
2011; 4: 188-194


Procedure-Type Risk Categories for Pediatric and Congenital Cardiac Catheterization

Lisa Bergersen, MD, MPH, Kimberlee Gauvreau, ScD, Audrey Marshall, MD, Jacqueline Kreutzer, MD, Robert Beekman, MD, Russel Hirsch, MD, Susan Foerster, MD, David Balzer, MD, Julie Vincent, MD, William Hellenbrand, MD, Ralf Holzer, MD, John Cheatham, MD, John Moore, MD, James Lock, MD and Kathy Jenkins, MD, MPH

Abstract

Background— The Congenital Cardiac Catheterization Project on Outcomes (C3PO) was established to develop outcome assessment methods for pediatric catheterization.

Methods and Results— Six sites have been recording demographic, procedural and immediate outcome data on all cases, using a web-based system since February 2007. A sample of data was independently audited for validity and data completeness. In 2006, participants categorized 84 procedure types into 6 categories by anticipated risk of an adverse event (AE). Consensus and empirical methods were used to determine final procedure risk categories, based on the outcomes: any AE (level 1 to 5); AE level 3, 4, or 5; and death or life-threatening event (level 4 or 5). The final models were then evaluated for validity in a prospectively collected data set between May 2008 and December 31, 2009. Between February 2007 and April 2008, 3756 cases were recorded, 558 (14.9%) with any AE; 226 (6.0%) level 3, 4, or 5; and 73 (1.9%) level 4 or 5. General estimating equations models using 6 consensus-based risk categories were moderately predictive of AE occurrence (c-statistics: 0.644, 0.664, and 0.707). The participant panel made adjustments based on the collected empirical data supported by clinical judgment. These decisions yielded 4 procedure risk categories; the final models had improved discrimination, with c-statistics of 0.699, 0.725, and 0.765. Similar discrimination was observed in the performance data set (n=7043), with c-statistics of 0.672, 0.708, and 0.721.

Conclusions— Procedure-type risk categories are associated with different complication rates in our data set and could be an important variable in risk adjustment models for pediatric catheterization.