Thursday, January 1, 2015

Sodium abnormalities

Review article: NEJM 2015;372:55-65.

Disorders of Plasma Sodium - Causes, Consequences, and Correction.

Abstract

This review considers the causes and consequences of an abnormal plasma sodium concentration and offers a framework for correcting it.
PMID:
 
25551526
 
[PubMed - as supplied by publisher]

Acute Kidney Injury detection after heart surgery in children

JACC 2014;64:2753-62

Combining functional and tubular damage biomarkers improves diagnostic precision of acute kidney injury after cardiac surgery.
Rajit K. Basu, et al. JACC 2014;64:2753-62.

Objective: Combining two biomarkers will improve precision of acute kidney injury (AKI) diagnosis after heart surgery in children.

Methods: n=345 children after cardiopulmonary bypass (CPB). Two biomarkers: Plasma Cystatin C & uNGAL were measured 2 hr after initiation of CPB.

Conclusion: Composites of plasma Cystatin C and uNGAL are superior to serum creatinine for predicting discrete characteristics of AKI.
(Click on the image to enlarge)